WebApr 13, 2024 · Under non-pathogenic conditions, mitochondria maintain a dynamic balance between fission and fusion events to create tubular networks for efficient energy production and distribution [18,19]. mHTT can also promote oxidative stress that disrupts the mitochondrial balance by over-expressing the pro-fission dynamin-related protein 1 … WebSep 21, 2024 · Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1). Potent active-site mTOR inhibitors engender mitochondrial hyperfusion due to the diminished translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding …
Mitochondrial fission requires DRP1 but not dynamins …
WebProtein probes, including ultrafiltrates from the placenta (UPla) and lung (ULu) of postnatal rabbits, were investigated in premature senescent HEK293 and HepG2 cells to explore whether they could modulate cellular senescence. Tris-Tricine–PAGE, gene ontology (GO), and LC–MS/MS analysis were applied to describe the characteristics of the … WebJul 19, 2003 · Protein Mitochondrial fission 1 protein Gene FIS1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 152 Protein … blackpool teaching hospitals trust board
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
WebApr 10, 2024 · We hypothesized that the mitochondrial dysfunction caused by mTORC2 deficiency might be due to the defect of mitochondrial fission which is governed by dynamin-related protein 1 (Drp1). Drp1 is the key pro-fission protein that is recruited from the cytosol to mitochondrial membranes where it oligomerizes and forms a ring-like … WebFission mediated through dynamin-related protein 1 (DRP1), which translocates from cytosol to the mitochondrial outer membrane and reacts with its receptor proteins … WebFeb 24, 2024 · Fis1 Antibody (C-10) is an IgG 1 κ mouse monoclonal Fis1 antibody (also designated Fis1 antibody or Mitochondrial fission 1 protein antibody) that detects Fis1 of mouse, rat and human origin by WB, IP, IF and ELISA. Fis1 Antibody (C-10) is available as the non-conjugated anti-Fis1 antibody form, as well as multiple conjugated forms of anti … blackpool teaching hospitals trust values